RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
miR-26a-5p
RNA ID
RNA Type
miRNA
Alteration Pattern
dysregulation
Species
mus musculus
Detection Methods
qRT-PCR; Masson's trichrome staining; etc.
Target
Ctgf; Smad4
Pathway
NA
PubMed ID
Title
The antifibrotic effects and mechanisms of microRNA-26a action in idiopathic pulmonary fibrosis
Year
2014
Function
"Downregulation of miR-26a in the lungs of mice with experimental pulmonary fibrosis and in IPF resulted in posttranscriptional derepression of connective tissue growth factor (CTGF), and induced collagen production. Inhibition of miR-26a in the lungs caused pulmonary fibrosis in vivo, whereas overexpression of miR-26a repressed transforming growth factor (TGF)-B1-induced fibrogenesis in MRC-5 cells and attenuated experimental pulmonary fibrosis in mice. MiR-26a was downregulated by TGF-B1-mediated phosphorylation of Smad3. Moreover, miR-26a inhibited the nuclear translocation of p-Smad3 through directly targeting Smad4, which determines the nuclear translocation of p-Smad2/Smad3."